https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14359 -ΔΔCt method was used to calculate the degree of expression. MTT assay showed the expression of miR-10b to have no effect on the proliferation of NPC cell lines. The wound healing assay showed that miR-10b mimics promoted the mobility and invasion of NPC cell lines. Inhibitors of miR-10b reduced the ability of NPC cell lines to migrate and invade. In addition, the expression of genes related to migration and invasion, such as E-cadherin, vimentin, and MMP-9, were confirmed to be different in the CNE-2Z NPC cell line transfected with miR-10b mimics and with miR-10b inhibitors. In the present study, miR-10b was found to upregulate the expression of MMP-9 and knockdown of miR-10b was found to significantly downregulate the expression of E-cadherin. On the whole, these results showed that miR-10b plays an important role in the invasion and metastasis of NPC cells.]]> Wed 11 Apr 2018 12:17:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19089 Sat 24 Mar 2018 08:05:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18033 Sat 24 Mar 2018 07:56:32 AEDT ]]>